Three molecular subtypes of SCLC were identified, with the smoking-related SBS4 signature showing the worst prognosis and lowest tumor mutational burden. The SBS13 signature was associated with a ...

(Boston)—Many different mutational signatures, or "fingerprints" of DNA damage have been identified across different tumor types which can provide a record of environmental exposure or clues about the ...

Occupational and environmental exposures can put specific groups of people at higher risk of cancer, including firefighters. A new study by investigators at Mass General Brigham examines a cancer ...

Clinical features and survival outcomes of small, node negative breast cancer: A multicenter, retrospective study. This is an ASCO Meeting Abstract from the 2025 ASCO Annual Meeting I. This abstract ...

Relationship Among DNA Damage Response Gene Alterations, Molecular Subtypes, and Survival Outcomes in Patients With Metastatic Bladder Cancer Treated on CALGB 90601 Sequencing data from 56,965 ...

Researchers from Japan report that they have characterized gene mutations in colorectal cancer (CRC) tumors with high tumor mutation burden that lack mutations in the major oncogenes. Their findings ...

New research reveals that years of firefighting may leave a deadly genetic mark, as toxic chemicals used on the job are now linked to brain cancer-causing mutations. Study: Glioma mutational ...

Gene mutations caused by exposure to certain chemical compounds have been linked to the development of gliomas, the most common type of malignant brain tumor. New research reveals that among patients ...